Articlesβ-Casomorphins Stimulate and Enterostatin Inhibits the Intake of Dietary Fat in Rats

Add time:09/02/2019    Source:sciencedirect.com

Lin, L., M. Umahara, D. A. York and G. A. Bray. β-casomorphins stimulate and enterostatin inhibits the intake of dietary fat in rats. Peptides 19(2) 325–331, 1998.—The effects of β-casomorphins 1–7, 1–5 and 1–4 on food intake of rats adapted to either a high fat (HF) or high carbohydrate (HC) diet have been studied and compared to the effects of enterostatin. Intracerebroventricular (icv) β-casomorphin1–7 (β-CM1–7) stimulated intake of HF diet in overnight fasted rats, but β-CM1–5 and β-CM1–4 were ineffective. Peripheral injection of β-CM1–7 also increased the intake of a high fat diet, but reduced the intake of HC diet in satiated rats. Intracerebroventricular (ICV) β-CM1–7 caused a dose-dependent increase in the intake of HF diet, but a dose-dependent inhibition of HC ingestion in satiated rats. Enterostatin (ICV) inhibited the β-CM1–7 stimulation of HF intake, as did the general opioid antagonist naloxone. Ligand binding studies with [3H-pro] enterostatin identified on low affinity binding site (Kd 100nM) on a crude brain membrane preparation. This binding was displaced by β-CM1–7, β-CM1–5 and β-CM1–4. These data suggest that at high doses enterostatin and β-CM1–7 may interact with the same low affinity receptor to modulate intake of dietary fat.

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