Dopamine D3 receptor antagonism contributes to Blonanserin (cas 132810-10-7)-induced cortical dopamine and acetylcholine efflux and cognitive improvement

Add time:08/28/2019    Source:sciencedirect.com

Blonanserin is a novel atypical antipsychotic drug (APD), which, unlike most atypical APDs, has a slightly higher affinity for dopamine (DA) D2 than serotonin (5-HT)2A receptors, and is an antagonist at both, as well as at D3 receptors. The effects of atypical APDs to enhance rodent cortical, hippocampal, limbic, and dorsal striatal (dSTR) DA and acetylcholine (ACh) release, contribute to their ability to improve novel object recognition (NOR) in rodents treated with sub-chronic (sc) phencyclidine (PCP) and cognitive impairment associated with schizophrenia (CIAS). Here we determined the ability of blonanserin, the D3 antagonist NGB 2904, and the typical APD, haloperidol, a D2 antagonist, to enhance neurotransmitter efflux in the medial prefrontal cortex (mPFC) and dSTR of mice, and to ameliorate the scPCP-induced deficit in NOR in rats. Blonanserin, 10 mg/kg, i.p., increased DA, norepinephrine (NE), and ACh efflux in mPFC and dSTR. NGB 2904, 3 mg/kg, increased DA and ACh, but not NE, efflux in mPFC, and DA, but not ACh, efflux in dSTR. Haloperidol increased DA and NE efflux in dSTR only. The selective D3 agonist PD 128907 partially blocked the blonanserin-induced cortical ACh, DA, NE and striatal DA efflux. NGB 2904, 3 mg/kg, like blonanserin, 1 mg/kg, and the combination of sub-effective doses of NGB 2904 and blonanserin (both 0.3 mg/kg), ameliorated the scPCP-induced NOR deficit in rats. These results suggest that D3 receptor blockade may contribute to the ability of blonanserin to increase cortical DA and ACh efflux, as well as to restore NOR and improve CIAS.

We also recommend Trading Suppliers and Manufacturers of Blonanserin (cas 132810-10-7). Pls Click Website Link as below: cas 132810-10-7 suppliers

Prev:Effectiveness of Blonanserin (cas 132810-10-7) for patients with drug treatment-resistant schizophrenia and dopamine supersensitivity: A retrospective analysis
Next:Atypical antipsychotic properties of AD-6048, a primary metabolite of Blonanserin (cas 132810-10-7))