Enantioselective synthesis of carbocyclic showdomycin derivative via asymmetric diels-alder reaction of (Ss)-3-(2-pyridylsulphinyl)acrylate

Add time:07/13/2019    Source:sciencedirect.com

The first enantioselective synthesis of a carbocyclic analogue of showdomycin, 3-[(1S,2S,3R,4R)2,3-(isopropylidenedioxy)-4-(pivaloxymethyl)cyclopentyl]maleimide 1, has been accomplished using the asymmetric Diels-Alder reaction of the (Ss)-3-(2-pyridylsulphinyl)acrylate 2 with cyclopentadiene as the key step.

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