1.04 - Mycolic Acid/Cyclopropane Fatty Acid/Fatty Acid Biosynthesis and Health Relations

Add time:08/25/2019    Source:sciencedirect.com

One of the most exciting fronts in research into infectious diseases in the current ‘genomic’ era is our expanding understanding of the chemical biology of the interaction of pathogens and their hosts. Much like their protein and nucleic acids counterparts, bacterial lipids and glycolipids are subject to evolutionary pressures that result in differential structure, variable expression levels, and differential ability of the host to recognize and respond to these factors. The pathogenesis of tuberculosis and related mycobacterial diseases is defining the leading edge of this emergent field and this chapter explores the structures, biosynthesis, and biological function of the diverse natural products that mediate human interactions with mycobacteria.

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