REGULAR ARTICLEAntithrombotic Effects of YS-49 and YS-51—1-Naphthylmethyl Analogs of Higenamine

Add time:08/25/2019    Source:sciencedirect.com

The antiplatelet and antithrombotic effects of YS-49 and YS-51—l-naphthylmethyl analogs of higenamine, which is a benzyl-tetrahydroisoquinoline alkaloid isolated from Aconitum japonicum (Ranunculaceae)—were investigated. YS-49 and YS-51 showed inhibitory activities to both human and rat platelet aggregation induced by ADP, collagen and epinephrine. They were more inhibitory to epinephrine-induced aggregation (IC50; 3.4 and 1.7 μM of YS-49, and 6.0 and 6.3 μM of YS-51 to human and rat platelets, respectively) than ADP- or collagen-induced aggregation. The antithrombotic effects of YS-49 and YS-51 were also observed in both mouse acute thrombosis model and rat arterio-venous shunt (AV shunt) model. The oral administration of YS-49 and YS-51 (50 or 100 mg/kg) increased the recovery rates from the acute thrombotic challenge in mice and lowered the weight of thrombus formed inside the AV shunt tube in rats.

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