The interaction of aminogroups with pyrroloquinoline quinone as detected by the reduction of nitroblue tetrazolium

Add time:09/01/2019    Source:sciencedirect.com

SummaryThe interaction of pyrroloquinoline quinone (PQQ) with amino groups was followed by measuring the capacity of adducts to reduce nitroblue tetrazolium (NBT). Of the natural amino acids only glycine, ornithine, and lysine interacted strongly with PQQ. The reducing acivity of other less reactive amino acids, but not of lysine, was increased by ammonia, primary or secondary amines. Divalent cations, in contrast inhibited development of NBT-reducing activity. PQQ also developed NBT-reactivity in the presence of seotonin and albumin. A reaction scheme is proposed which explains these findings. It is suggested that the NBT-reducing activity of plasma which is not caused by glycation of plasma proteins, arises from PQQ adducts inherrent to plasma. This NBT-reducing activity corresponds to approximately 10 ug PQQ/ml plasma.

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