Synthesis of novel fluorine- and iodine-containing [1,2,4]triazolo[3,4-b][1,3]thiazines based 3-(alkenylthio)-5-(trifluoromethyl)-4H-1,2,4-triazole-3-thiols

Add time:08/25/2019    Source:sciencedirect.com

In this paper we report the synthesis of novel S-alkenyl derivatives of 5-(trifluoromethyl)-4H-1,2,4-triazole-3-thiol via alkenation reaction with different alkenyl halides. Reaction between the resulting S-alkenation products and iodine proceeds regiospecifically to give new fused fluorine- and iodine-containing [1,2,4]triazolo[3,4-b][1,3]thiazine heterocyclic systems. The structure of synthesized compounds was confirmed by mass spectra, IR, 1H, 13C and 19F NMR spectroscopy including 2D 1H–13C HSQC, 1H–1H COSY, 1H–13C HMBC correlations, elemental analysis and single-crystal X-ray diffraction study.

We also recommend Trading Suppliers and Manufacturers of 2-METHYL-4-[(3-TRIFLUOROMETHYL)PHENYL]-1-BUTENE (cas 113947-87-8). Pls Click Website Link as below: cas 113947-87-8 suppliers

Prev:Preparation and crystal structure determination of adducts of copper(II) chloride with 3-aryl-1-(imino-pyridin-2-yl-methyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazoles
Next:Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists)