Reactivity of N-protected 5-(2-bromophenyl)tetrazoles in palladium-catalyzed direct arylation of heteroarenes or fluorobenzenes

Add time:08/25/2019    Source:sciencedirect.com

A new route allowing the one-step synthesis of (2-heteroarylphenyl)tetrazole and fluorinated biphenyltetrazole derivatives is disclosed. By using 2 mol% of an air-stable diphosphine-palladium catalyst [PdCl(C3H5)(dppb)], potassium pivalate as base and dimethylacetamide as solvent, a wide range of heteroarenes (e.g., thiazoles, (benzo)thiophenes, furans, pyrroles, and imidazo[1,2-a]pyridine) and polyfluorobenzenes was easily coupled with N-protected (2-bromophenyl)tetrazoles in high yields.

We also recommend Trading Suppliers and Manufacturers of 2-(2-Bromophenyl)-2-methylpropionic acid (cas 113948-00-8). Pls Click Website Link as below: cas 113948-00-8 suppliers

Prev:Young Scientist Feature1H, 13C NMR and ESI–MS studies of 1:1 complexes of some sulfenyl carbon acids with 1,5,7-triazabicyclo[4.4.0]dec-5-ene in solution
Next:Increased binding to sigma sites of N-[1′(2-piperidinyl)ethyl)-4-[I-125]-iodobenzamide (I-125-PAB) with onset of tumor cell proliferation)