Enantioselective synthesis of aziridine 2,2-dicarboxylates. Part I: Copper(II)-bisoxazoline complex-catalysed Michael reaction on alkylidene malonates

Add time:08/26/2019    Source:sciencedirect.com

The preparation of aziridine-2,2-dicarboxylates via 1,4-addition of N,O-bis(trimethylsilyl)hydroxylamine to α,β-unsaturated malonates in the presence of chiral Lewis acids is reported. Good enantioselectivity was observed for conjugate addition catalysed by [Cu(S,S)-Bn-(box)](OTf)2 on isobutylidene and 3-methylbutylidene malonate.

We also recommend Trading Suppliers and Manufacturers of DIETHYL (1-METHYLBUTYL)MALONATE (cas 117-47-5). Pls Click Website Link as below: cas 117-47-5 suppliers

Prev:Synthesis and liquid crystalline properties of novel fluorinated N-benzoyl thiourea compounds. Effect of perfluoroalkyl chains on the thermal behavior and smectic phases stability
Next:Ice-like encapsulated water by two cholic acid moieties)