Design and synthesis of phthalimide-type histone deacetylase inhibitors

Add time:08/27/2019    Source:sciencedirect.com

Several hydroxamic acid derivatives with a substituted phthalimide group as a linker and/or cap structure, prepared during structural development studies based on thalidomide, were found to have histone deacetylase (HDAC)-inhibitory activity. Structure–activity relationship studies indicated that nature of the substituent introduced at the phthalimide nitrogen atom, introduction of a hydroxamic acid structure, and distance between the N-hydroxyl group and the cap structure are important for HDAC-inhibitory activity.

We also recommend Trading Suppliers and Manufacturers of N-(Hydroxymethyl)phthalimide (cas 118-29-6). Pls Click Website Link as below: cas 118-29-6 suppliers

Prev:Aqueous degradation of N-(hydroxymethyl)-phthalimide in the presence of specific and general bases. Kinetic assessment of N-hydroxymethyl derivatives of nitrogen heterocycles as possible prodrugs
Next:The novel product of cathodic reduction of phthalimide anion)