Sarasinosides D-G: four new triterpenoid saponins from the sponge asteropus sarasinosum

Add time:08/26/2019    Source:sciencedirect.com

Four new triterpenoid oligoglycosides (2–5; sarasinosides D–G, respectively) and sarasinoside B1 (1) have been isolated from the butanolic extracts of the sponge Asteropus sarasinosum, which showed in vitro cytotoxic activity against several types of tumour cells and inhibition to protein kinase C. These compounds have identical sugar chains and differ in the aglycon moiety. Structures were established by FAB-MS, COSY, XHCORR, RCOSY, TOCSY, ROESY and HMQC experiments, and confirmed by selective hydrolysis and permethylation followed by methanolysis.

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