Technical noteEfficient synthesis of the 18F-labelled 3-O-methyl-6-[18F]fluoro-L-DOPA

Add time:08/26/2019    Source:sciencedirect.com

The 18F-labelled amino acid derivative 3-O-methyl-6-[18F]fluoro-l-DOPA ([18F]OMFD) is a potential radiotracer for imaging tumour tissue using positron emission tomography. The precursor N-formyl-3-O-methyl-4-O-boc-6-trimethyl-stannyl-l-DOPA-ethyl ester enables direct electrophilic radiofluorination by stereoselective destannylation. After partial hydrolysis, optimized HPLC purification and sterile filtration, the [18F]OMFD obtained with high radiochemical purity and ready for use. The total synthesis time is about 50 min and the radiochemical yield achieved is 20–25% (decay corrected, related to [18F]F2). It was demonstrated that [18F]OMFD could be produced routinely and reliably for clinical use. [18F]FDOPA-preparation devices can be used with minor modifications.

We also recommend Trading Suppliers and Manufacturers of 3-O-Methyl-6-fluoro-L-Dopa, OMFD (cas 114077-01-9). Pls Click Website Link as below: cas 114077-01-9 suppliers

Prev:Design and synthesis of metabolically stable atrial natriuretic factor analogs: Amino- and carboxy-terminal stabilization
Next:Original articleα- and β-hydrazino acid-based pseudopeptides inhibit the chymotrypsin-like activity of the eukaryotic 20S proteasome)