Separation and characterization of homopipecolic acid isoflavonoid ester derivatives isolated from Ononis spinosa L. root

Add time:08/26/2019    Source:sciencedirect.com

Spiny restharrow root (Ononis spinosa L.) and its preparations are mainly used for the treatment of urinary infections or bladder stones in numerous countries. Spiny restharrow root is rich in isoflavonoids (formononetin, calycosin and pseudobaptigenin), pterocarpans (medicarpin and maackiain) and dihydroisoflavonoids (onogenin and sativanone), which metabolites are present as glucosides, glucoside malonates, glucoside acetates and free aglycones in the root. The in-depth analysis of tandem mass spectrometric (MS) and high-resolution MS (HR-MS) data revealed the presence of nitrogen-containing compounds in the root extracts. An ion-exchange-based purification and a preparative-scale reversed phase chromatographic isolation procedure was developed for the characterization of these new natural products. For the unambiguous identification of the isolated compounds NMR experiments were carried out. The thorough characterization confirmed the presence of six piperidin-2-yl-acetic acid (homopipecolic acid) esters of isoflavonoid glucosides. This is the first report of homopipecolic acid esters isolated from higher plants.

We also recommend Trading Suppliers and Manufacturers of ACETIC ACID 1-(3-METHOXY-PHENYL)-BUT-3-ENYL ESTER (cas 114095-72-6). Pls Click Website Link as below: cas 114095-72-6 suppliers

Prev:Metal-free and metallophthalocyanines appending with eight 12-crown-4 ethers
Next:Research paperDesign, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase)