Catalyst- and steric-controlled alkenylation via chemoselective C–H activation and C–Br activation in Heck reaction of methyl 1-(2-bromoaryl)-3-(2-furyl/thienyl)-5-oxopyrrolidine-2-carboxylates and diethyl 1-(2-bromoaryl)-3-(2-furyl/thienyl)-5-oxopyrrolidine-2,2-dicarboxylate derivatives

Add time:08/27/2019    Source:sciencedirect.com

Pd(II)-catalyzed alkenylation of methyl 1-(2-bromoaryl)-3-(2-furyl/thienyl)-5-oxopyrrolidine-2-carboxylate derivatives 1(a–d) resulted in the formation of 3(a–d) exclusively via C–H activation in the heteroaryl moiety. Similar observations were observed for the corresponding diester analogues 4(a–d) to form 5(a–d). Normal Heck reaction, however, was observed in the case of 1(a–f) to furnish 2(a–f) when the reaction was carried out with Pd(0) catalyst generated in situ. Pd(0)-catalyzed vinylation of 4(a–f) via C–Br oxidation, however, failed due to steric reason.

We also recommend Trading Suppliers and Manufacturers of 6-(2-FURYL)-2-OXO-4-(2-THIENYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE (cas 111121-81-4). Pls Click Website Link as below: cas 111121-81-4 suppliers

Prev:2-Thienyl-4-furyl-6-aryl pyridine derivatives: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study
Next:Reactivity of the triruthenium ortho-metalated cluster [Ru3(CO)9{μ3-η1,κ1,κ2-PhP(C6H4)CH2PPh}] with tri(2-thienyl)phosphine and tri(2-furyl)phosphine: Formation of 1,3-diphenyl-2,3-dihydro-1H-1,3-benzodiphosphine complexes via phosphorus–carbon bond formation)