TRYPSIN INHIBITOR (cas 12786-39-9)s for the treatment of pancreatitis
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Add time:08/31/2019 Source:sciencedirect.com
Proline-based trypsin inhibitors occupying the S1–S2–S1′ region were identified by an HTS screening campaign. It was discovered that truncation of the P1′ moiety and appropriate extension into the S4 region led to highly potent trypsin inhibitors with excellent selectivity against related serine proteases and a favorable hERG profile.
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