Original articleSynthesis and antineoplastic evaluation of N-enamine derivatives of 1,4-bis[(2-aminoethyl)amino]-9,10-anthracenedioneSynthèse et évaluation antinéoplastique de dérivés N-énaminiques de la 1,4-bis[(2-aminoethyl)amino]-9,10-anthracènedione

Add time:09/04/2019    Source:sciencedirect.com

Several N-enamine derivatives of 1,4-bis[(2-aminoethyl)amino]-9,10-anthracenedione have been synthesized in the reaction of 1,4-bis[(2-aminoethyl)amino]-9,10-anthracenedione with various β-dicarbonyl compounds. The obtained derivatives exhibited cytotoxicity in vitro comparable or lower to that of ametantrone but their in vivo activity against P388 murine leukemia was decreased.

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