Research Articlesdl-2,6-Diamino-4-hexynoic acid (cas 13004-67-6), a Growth Inhibitor

Add time:08/28/2019    Source:sciencedirect.com

dl-2,6-Diamino-4-hexynoic acid, a lysine analog, was synthesized by the interaction of N-(4-chloro-2-butynyl)phthalimide and the sodium salt of ethyl acetamidomalonate. A two-step hydrolysis yielded the desired acetylenic diamino acid. dl-Lysine, identical with the known amino acid, was obtained by the reduction of the triple bond in I. This acetylenic analog of lysine inhibited the growth of DNA, RNA, and protein synthesis in resting cell suspensions of pneumococci at a concentration of 100 mcg./ml.

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