ReviewThe role and mechanism of microbial 3-ketosteroid Δ1-dehydrogenases in steroid breakdown

Add time:08/27/2019    Source:sciencedirect.com

3-Ketosteroid Δ1-dehydrogenases are FAD-dependent enzymes that catalyze the introduction of a double bond between the C1 and C2 atoms of the A-ring of 3-ketosteroid substrates. These enzymes are found in a large variety of microorganisms, especially in bacteria belonging to the phylum Actinobacteria. They play a critical role in the early steps of the degradation of the steroid core. 3-Ketosteroid Δ1-dehydrogenases are of particular interest for the etiology of some infectious diseases, for the production of starting materials for the pharmaceutical industry, and for environmental bioremediation applications. Here we summarize and discuss the biochemical and enzymological properties of these enzymes, their microbial sources, and their natural diversity. The three-dimensional structure of a 3-ketosteroid Δ1-dehydrogenase in connection with the enzyme mechanism is highlighted.

We also recommend Trading Suppliers and Manufacturers of (5α,9α,10β)-2α-Hydroxy-4β-(hydroxymethyl)-4,8β-dimethyl-18-nor-16-oxaandrosta-13(17),14-diene-3-one (cas 111139-69-6). Pls Click Website Link as below: cas 111139-69-6 suppliers

Prev:Synthesis and new rearrangements of 4-isoxazolin-4,5-dicarboxylic acid derivatives
Next:Synthesis, physicochemical properties and membrane interaction of novel quaternary ammonium surfactants derived from l-Tyrosine and l-DOPA in relation to their antimicrobial, hemolytic activities and in vitro cytotoxicity)