Full paper/MémoireCerium(IV) triflate-catalyzed domino annulation approaches to the synthesis of highly substituted piperidines
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Add time:08/27/2019 Source:sciencedirect.com
A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using cerium(IV) triflate as a catalyst is described. In most cases, the piperidine precipitates out of the solution.
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