Synthesis and biological evaluation of new nucleosides derived from trifluoromethoxy-4-quinolones
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Add time:08/27/2019 Source:sciencedirect.com
The synthesis of new nucleoside derivatives from 6- and 7-trifluoromethoxy-4-quinolones is described. The present synthesis is a combination of the Gould–Jacobs reaction for the preparation of 4-quinolones and a modified Vorbrüggen reaction for the construction of nucleoside derivatives. The target compounds were tested against murine gammaherpesvirus MHV-68 type.
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