Axonal flow blockade induces α-CGRP mRNA expression in rat motoneurons

Add time:08/29/2019    Source:sciencedirect.com

Axonal flow of motoneurones was blocked in the sciatic nerve by the application of vinblastine at a low concentration (100 μM) not considered likely to cause axonal degeneration. The number of motoneurons expressing α-calcitonin gene-related peptide (CGRP) mRNA was significantly increased by vinblastine application, while the expression of ß-CGRP mRNA was not influenced. These findings suggest that the synthesis of these two peptides is differentially regulated and that α-CGRP mRNA is possibly down-regulated by unknown factor(s) which normally undergo retrograde transport from the periphery.

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