Human and rat α-CGRP but not calcitonin cause mesenteric vasodilatation in rats

Add time:08/28/2019    Source:sciencedirect.com

A single gene encodes both calcitonin and the calcitonin gene-related peptide (CGRP). Human and rat α-CGRP were compared with sodium nitroprusside in the rat and rabbit isolated mesenteric vascular preparation perfused at constant flow. In the presence of the vasoconstrictor noradrenaline (10−5 M), rat α-CGRP was about 10 times as potent as either human α-CGRP or sodium nitroprusside as a vasodilator in the rat mesenteric vasculature. In the rabbit mesenteric vasculature the order of potency was rat α-CGRP > human α-CGRP > sodium nitroprusside. Human and salmon calcitonin showed no vasodilator activity at doses 100 times greater than human α-CGRP. These results show that human and rat α-CGRP are potent vasodilators in the mesenteric vasculature, an effect not mimicked by the alternative gene product, the plasma calcium lowering hormone calcitonin.

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