Total synthesis of (−)-hispanolone and an improved approach towards prehispanolone (cas 132922-55-5)

Add time:08/29/2019    Source:sciencedirect.com

On the basis of the recently reported construction of (±)-hispanolone (2), the enantiomerically pure form of (−)-2, employed in our partial synthesis of the specific platelet activating factor receptor antagonist prehispanolone (3), was prepared from (S)-(+)-Wieland-Miescher ketone (1). Moreover, an improvement of the literature synthesis en route to prehispanolone (3) starting from synthetic (−)-hispanolone (2) was also carried out.

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