Towards the synthesis of swinholide A and scytophycin C. A highly stereocontrolled synthesis of (−)-pre-swinholide A
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Add time:08/29/2019 Source:sciencedirect.com
The fully protected monomeric unit 19 of the marine macrodiolide, swinholide A (1), was obtained with > 97% ds by a Mukaiyama aldol reaction between 16 and 5, followed by a boron-mediated reduction to give the syn 1,3-diol 18. Deprotection gave (−)-pre-swinholide A (2), the putative biosynthetic precursor of 1.
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