Chapter 1 - Recent Development in the Chemistry of Bicyclic 6–6 Systems Containing One Bridgehead Nitrogen Atom and One Extra Heteroatom and Their Benzologs: An update

Add time:08/27/2019    Source:sciencedirect.com

Publisher SummaryThis chapter covers bi- and tricyclic ring systems, highlighting recent development in the chemistry of bicyclic 6–6 systems containing one bridgehead nitrogen atom and one extra heteroatom and their benzologs. The members of these ring systems occupy valuable parts of the chemical space for drug research, as most of their derivatives have drug-like properties and their outstanding representatives play an indispensable role in medicinal chemistry. The chapter focuses on recent research on pyrido[1,2-b][1,2]oxazines, pyrido[1,2-b][1,2]thiazines, pyrido[1,2-b]pyridazines, pyrido[1,2-c][1,3]oxazines, pyrido[1,2-c][1,3]thiazines, pyrido[1,2-c]pyrimidines, pyrido[2,1-c][1,4]oxazines, pyrido[2,1-c][1,4]thiazines, and pyrido[1,2-a] pyrazines and their benzologs, related to their structure, reactivity, synthesis, applications, and important compounds.

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