N-α-Fmoc-4-phosphono(difluoromethyl)-L-phenylalanine: A new O-phosphotyrosine isosteric building block suitable for direct incorporation into peptides

Add time:08/27/2019    Source:sciencedirect.com

An efficient preparation of N-α-Fmoc-4-phosphono(difluoromethyl)-L-phenylalanine 5 is described. The synthesis of this phosphotyrosine isostere involves deprotection of the penultimate diethylphosphonate intermediate 4 with BSTFA/TMSI as the key step. Building block 5 can be utilized directly for incorporation into peptides without protection of the side chain phosphonic acid group, as illustrated by the efficient preparation of model difluorophosphonopeptides Ac-F2Pmp-Ile-Asn-Gln-NH2 and Ac-Glu-F2Pmp-Ile-Asn-Gln-NH2.

We also recommend Trading Suppliers and Manufacturers of Fmoc-Glu(OBut)-ODhbt (cas 114119-86-7). Pls Click Website Link as below: cas 114119-86-7 suppliers

Prev:Z-scan studies on organic crystal (E)-1-(2-chlorobenzylidene) cyclododecane-1-one for photonic applications
Next:Enantioselective synthesis of (L)-Fmoc-α-Me-Lys(Boc)-OH via diastereoselective alkylation of oxazinone as a chiral auxiliary)