N-Nitroso Compounds in Foods

Add time:08/28/2019    Source:sciencedirect.com

N-nitroso compounds (NOC) are a class of potent environmental carcinogens and some NOC have been classified as “probably” or “possibly” carcinogenic to humans. NOC are chemically rather simple compounds, encompassing N-nitrosamines and N-nitrosamides, and compounds carrying further functional groups, such as certain N-nitrosated amino acids. Chemical and biological properties are primarily governed by the respective NOC structure. NOC are generated by reaction of precursor molecules with nitrosating agents. The basic reaction mechanisms and formation pathways, including in-vivo formation, are being delineated. In addition, the occurrence of NOCs in major food classes is reviewed in connection with estimates of resulting human exposure. The toxicological properties and the toxicokinetics are summarized within the frame of current concepts and approaches for risk assessment.

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