Release of pituitary melanocyte-stimulating hormone by the oxytocin fragment, H-Cys-Tyr-Ile-Gln-Asn-OH

Add time:08/30/2019    Source:sciencedirect.com

The effect of the pentapeptide H-Cys-Tyr-Ile-Gln-Asn-OH to act like melanocyte-stimulating hormone-releasing factor (MSH-RF) was studied. This peptide decreases at ng amounts the MSH content of the rat pituitary and increases plasma MSH concentration. This agent also stimulates the release of MSH in animals with eminence lesion, indicating a direct action of the pentapeptide on the gland.

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