Original articleSynthesis, photochemical E (trans) → Z (cis) isomerization and antimicrobial activity of 2-Chloro-5-MethylPyridine (cas 18365-64-4)-3-olefin derivatives

Add time:08/27/2019    Source:sciencedirect.com

2-Chloro-5-methylpyridine-3-olefin derivatives (3a-e) have been synthesized from 2-chloro-5-methylnicotinaldehyde (1) and studied their photochemical E (trans) → Z (cis) isomerization upon direct irradiation and triplet sensitized excitation for the first time. The triplet sensitized excitations of the compounds yielded high Z (4a–e) isomer composition, whereas the direct excitation results in less Z (4a–e) isomer composition, indicating triplet pathway is very efficient in converting the E (trans) → Z (cis) isomer. Thus synthesized E (3a–c and 3e) and generated Z (4a–c and 4e) isomers were tested for antimicrobial activity. Antifungal activity of these pyridine derivatives are closely comparable to the standard used.

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