communication / preliminary communicationSynthèse de nouvelles 7 (5)-〚benzimidazol-2-yl〛méthyl-2 (7)-méthyl-1,2,4-triazolo〚1,5-a〛(〚4,3-a〛)pyrimidinesSynthesis of new 7 (5)-〚benzimidazol-2-yl〛methyl-5 (7)-methyl-1,2,4-triazolo〚1,5-a〛(〚4,3-a〛)pyrimidines.

Add time:08/29/2019    Source:sciencedirect.com

Condensation of 4-hydroxy-6-methyl pyran-2-one 2 with 3-amino-1,2,4-triazole 1 in refluxing alcohol afforded 5-alkoxycarbonylmethyl-7-methyl-1,2,4-triazolo〚1,5-a〛pyrimidines and their isomers 5-alkoxycarbonylmethyl-7-methyl-1,2,4-triazolo〚4,3,-a〛pyrimidines 4. Reaction of hydrazine hydrate with compounds 4 and 5 yielded the corresponding hydrazid acids 6 and 7. Condensation of o-phenylenediamines 8 with esters 3(4) in refluxing xylol or with hydrazid acid 6(7) by melting reagents afforded 7(5)-〚benzimidazol-2-yl〛methyl-5(7)methyl-1,2,4-triazolo〚1,5-a〛(〚4,3-a〛)pyrimidines 9(10). The structures of the annealed compounds have been elucidated by their 1H, 13C NMR and Mass Spectroscopy data.

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