Case ReportRole of dantrolene in dinitrophenol (DNP (cas 119-26-6)) overdose: A continuing question?☆☆☆☆☆☆

Add time:09/06/2019    Source:sciencedirect.com

Background2,4-Dinitrophenol (DNP) is a known uncoupler of oxidative phosphorylation that clinically results in hyperthermia, tachycardia, tachypnea, and metabolic acidosis. Overdoses of DNP are often fatal and there is no specific reversal therapy. Dantrolene interferes with calcium release in skeletal muscle and is traditionally used to treat malignant hyperthermia. There has been limited published data on its use in DNP toxicity. We present two cases of DNP toxicity that were treated with dantrolene.

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