Cytotoxicity of XANTHOPTERIN (cas 119-44-8) and isoXANTHOPTERIN (cas 119-44-8) in MCF-7 cells

Add time:08/29/2019    Source:sciencedirect.com

Human mammary carcinoma MCF-7 cell line responsiveness to the pteridines XANTHOPTERIN (cas 119-44-8) and isoxanthopterin was studied using the MTS assay for measurement of cell viability. The pteridines were tested at concentrations ranging from 7.8 to 500 μM singly and in 11 isoxanthopterin:xanthopterin ratios. IC50s of xanthopterin and isoxanthopterin were 109±13 μM (mean±SEM of y estimate) and 103±9 μM, respectively. The IC50 values for pteridine mixtures were similar although 3:1 and 4:1 isoxanthopterin:xanthopterin ratios seemed slightly more cytotoxic than other mixtures. However, ANOVA revealed no statistical differences in the cytotoxicity of mixtures.

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