The effect of copolymerized 9,10-DIHYDROXYSTEARIC ACID (cas 120-87-6) on erosion rates of poly(ortho esters) and its use in the delivery of levonorgestrel
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Add time:08/31/2019 Source:sciencedirect.com
Erosion, rates of poly(ortho esters) can be usefully accelerated by the copolymerization of 9,10-DIHYDROXYSTEARIC ACID (cas 120-87-6) into the copolymer. This accelerating effect can be enhanced by using a hydrophilic diol such as triethylene glycol as one of the monomers. By using a combination of 9,10-dihydroxystearic acid and triethylene glycol precise control over erosion rate of the polymer can be achieved by small variations in the amount of 9,10-dihydroxystearic acid used. This technique has been used to develop levonorgestrel-containing devices.
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