Multicomponent reaction of pyridine, acetoacetamide/benzoylacetamides and sulfuryl chlorides: regioselective construction of 4-olefinated dihydropyridines

Add time:08/31/2019    Source:sciencedirect.com

A new, operationally simple one-pot method has been developed for the regioselective synthesis of a series of novel 4-olefinated dihydropyridines bearing various functional groups from the reaction of pyridine, acylacetamides, and sulfuryl chlorides under mild conditions. In this multicomponent process, subsequent the activation of pyridine by sulfuryl chloride/nucleophilic addition of acylacetonitrile formed in situ/enolization/sulfonylation leads to the formation of final products.

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