Primapterin, anapterin (cas 13019-53-9), and 6-oxo-primapterin, three new 7-substituted pterins identified in a patient with hyperphenylalaninemia

Add time:08/28/2019    Source:sciencedirect.com

SummaryThree unknown compounds present in the urine of a patient with mild hyperphenylalaninemia were identified to be L-erythro-7-iso-biopterin, D-erythro-7-iso-neopterin, and L-erythro-6-oxo-7-iso-biopterin. The newly identified pterins were named primapterin, anapterin, and 6-oxo-primapterin, respectively.Primapterin and anapterin are present in very low concentrations in every human urine, as well as in the liver of man and mouse, whereas 6-oxo-primapterin was detected in the patient's urine only. Substantial amounts of primapterin were excreted in the patient described.The metabolic origin of primapterin and anapterin is still obscure.

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