Total synthesis of cirsimarin (cas 13020-19-4) and evidence of its lipolytic and antilipogenic activities on human adipocytes

Add time:08/29/2019    Source:sciencedirect.com

A straightforward procedure leading to the flavone cirsimaritin and its 4′-O-β-d-glycosylation to afford cirsimarin (cas 13020-19-4), its corresponding flavone glucopyranoside, is described. The biological properties of cirsimarin, measured on human adipocytes, showed potent effects on both lipolysis and lipogenesis. Cirsimarin could therefore be considered as an efficient tool in the struggle against excessive adipose tissue deposition and as a potential candidate in the treatment of obesity.

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