A simple and facile method for the synthesis of novel 5/7 trifluoromethyl-substituted 4(3H)-quinazolone regioisomers

Add time:08/31/2019    Source:sciencedirect.com

The unsymmetrical 1,3-diketones 1 on reaction with malononitrile is resulted an interesting trifunctional intermediates 2 and 3. The intermediate 2 is hydrolyzed to give 2,6-dicarboxamido aniline 4 which on cyclisation gave two regioisomers of 1,2-dihydro-4(3H)-quinazolinones 5 and 6. The effect of substituents on compound 4 is characteristic for formation of regioisomers in different proportions. Each regioisomer on dehydrogenation under mild condition using active MnO2 gave corresponding 4(3H)-quinazolones 7 and 8, respectively.

We also recommend Trading Suppliers and Manufacturers of 4(3H)-Pyrimidinethione, 3,6-dimethyl-2-phenyl- (cas 114197-32-9). Pls Click Website Link as below: cas 114197-32-9 suppliers

Prev:Research paperC8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays
Next:11.02 - Bicyclic 5-5 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: One Extra Heteroatom 1:0)