Concise synthesis of thapsigargin from nortrilobolide (cas 136051-63-3)

Add time:08/28/2019    Source:sciencedirect.com

Herein, we describe an expedient synthesis of the hexaoxygenated guaianolide thapsigargin (1), a potent inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), from the natural product nortrilobolide (2). This protocol involves three key steps: the one-pot substitution-oxidation reaction of an allylic ester into its corresponding α,β-unsaturated ketone, subsequent stereoselective α′-acyloxylation in the presence of Mn(OAc)3, and a highly stereoselective ketone reduction.

We also recommend Trading Suppliers and Manufacturers of nortrilobolide (cas 136051-63-3). Pls Click Website Link as below: cas 136051-63-3 suppliers

Prev:Effect of lentinan on membrane-bound protein expression in splenic lymphocytes under chronic low-dose radiation
Next:Parental opinions towards the “No (cas 136055-64-6) Jab, No (cas 136055-64-6) Pay” policy in Australia)