Comparison of the antiviral activities of 3′-azido-3′-deoxythymidine (AZT) and gossylic iminolactone (cas 136105-62-9) (GIL) against clinical isolates of HIV-1

Add time:08/28/2019    Source:sciencedirect.com

3′-Azido-3′-deoxythymidine (AZT) and gossylic iminolactone (cas 136105-62-9) (GIL) were compared for antiviral activities in vitro against fresh clinical isolates of HIV-1 obtained from 19 subjects on AZT therapy. IC50 values for AZT ranged from 0.015 to 6.7 μM (447-fold range) while IC50 values for GIL ranged from 0.40 to 6.6 μM (16-fold range). There was no correlation between IC50 values for AZT and GIL, suggesting that the anti-HIV activity of GIL does not involve inhibition of reverse transcriptase.

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