New stereoselective methodology for the synthesis of Dihydroxerulin (cas 132971-60-9) and xerulin, potent inhibitors of the biosynthesis of cholesterol

Add time:08/29/2019    Source:sciencedirect.com

A new stereoselective methodology for the synthesis of both Dihydroxerulin (cas 132971-60-9) and xerulin has been devised. The key step required cross-coupling reactions between the bromo trienyne, (1E,3E,5E)-1-bromo-8-trimethylsilyl-1,3,5-octatrien-7-yne and the appropriate conjugated diynes. The palladium-catalyzed tandem cross-coupling/cyclization reaction of the resulting polyenynes with (Z)-3-iodo-2-propenoic acid led directly to dihydroxerulin or xerulin with a high degree of stereoselectivity.

We also recommend Trading Suppliers and Manufacturers of Dihydroxerulin (cas 132971-60-9). Pls Click Website Link as below: cas 132971-60-9 suppliers

Prev:ArticleTyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity
Next:A New Stereocontrolled Synthesis of Dihydroxerulin (cas 132971-60-9), a Potent Noncytotoxic Inhibitor of the Biosynthesis of Cholesterol)