Receptor from Streptococcus pyogenes as a potential antidote against sperm immobilization factor-induced sperm impairment and infertility

Add time:08/30/2019    Source:sciencedirect.com

The present study was undertaken to demonstrate the existence of mimicry between spermatozoa and bacteria. For this, the shared antigenic determinants between mouse spermatozoa and Streptococcus pyogenes against a common ligand, sperm immobilization factor (SIF), were isolated. The mimicry was established on the basis of their ability to ameliorate the SIF-mediated compromised sperm parameters in vitro viz. motility, viability, morphology and Mg2+-ATPase activity of spermatozoa. Further, both the receptors i.e. SIF-binding receptor from mouse spermatozoa (MS-SBR) and SIF-binding receptor from S. pyogenes (S-SBR) were able to block the binding of FITC-labelled SIF to spermatozoa and bacteria. The in vivo studies also showed that MS-SBR (10 μg)/S-SBR (25 μg) could alleviate SIF-induced infertility in female BALB/c mice, further providing evidence for molecular similarities between bacteria and spermatozoa.

We also recommend Trading Suppliers and Manufacturers of nuclear autoantigenic sperm protein (cas 132989-56-1). Pls Click Website Link as below: cas 132989-56-1 suppliers

Prev:ReproArrayGTS: A cDNA microarray for identification of reproduction-related genes in the giant tiger shrimp Penaeus monodon and characterization of a novel nuclear autoantigenic sperm protein (cas 132989-56-1) (NASP) gene
Next:The nuclear status of human sperm cells)