Short communication[3H]PCP-3-OH and (+)[3H]SKF 10047 binding sites in rat brain membranes: evidence of multiplicity

Add time:09/01/2019    Source:sciencedirect.com

Specific binding of one of the most potent analogs of phencyclidine (PCP), [3H]PCP-3-OH, in rat brain membranes revealed the labeling of high (Kd = 0.5 nM) and low (Kd = 16 nM) affinity binding sites. (+)SKF 10047 potently inhibited high, but not low, affinity [3H]PCP-3-OH binding. (+)[3H]SKF 10047 apparently labeled the high affinity PCP-3-OH binding site and also an additional site, sensitive to haloperidol, which is distinct from the two sites labeled by [3H]PCP-3-OH.

We also recommend Trading Suppliers and Manufacturers of SKF-10047 (cas 133005-41-1). Pls Click Website Link as below: cas 133005-41-1 suppliers

Prev:Rapid communicationIP3 receptor antagonist heparin uncompetitively inhibits [3H](+)-SKF-10047 (cas 133005-41-1) binding to σ receptors
Next:[3H]-SKF 10047 binding to rat brain membranes: Evidence for kappa isoreceptors)