The absorption and biotransformation of glyceryl trinitrate-1,3-14C by rats
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Add time:09/01/2019 Source:sciencedirect.com
The metabolism of 14C-labeled glyceryl trinitrate was studied in the rat. Absorption, tissue distribution and elimination were followed after administering a single dose by gavage. Thin-layer chromatography and radio-scanning methods were employed to assay urinary drug metabolites, including the isomeric glyceryl dinitrates and glyceryl monoitrates. It was found that glyceryl trinitrate was absorbed and transformed very rapidly. The major products were carbon dioxide, urinary glycerol, glyceryl nitrates, organic acids and some unidentified tissue components which were also labeled with 14C.
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