The pheomelanin precursor 5-S-Cysteinyldopa (cas 19641-92-0) protects melanocytes from membrane damage induced by ultraviolet A radiation
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Add time:08/29/2019 Source:sciencedirect.com
Pheomelanin and pheomelanin precursors have been implicated as risk factors for induction of melanoma by ultraviolet radiation. The pheomelanin precursor, 5-S-cysteinyldopa, has been shown to sensitise DNA to oxidative damage by ultraviolet radiation. We here show that 5-S-cysteinyldopa significantly protects melanocytes from membrane damage (permeability) induced by ultraviolet A radiation. Thus, 5-S-cysteinyldopa, may at the same time sensitise DNA and protect membranes from damage induced by ultraviolet radiation.
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