Antagonism between bicuculline, strychnine, and picrotoxin and depressant amino-acids in the rat nervous system

Add time:09/02/2019    Source:sciencedirect.com

1.1. The effects of the alkaloids bicuculline, strychnine, and picrotoxin on the actions of the depressant amino-acids glycine, GABA, β-hydroxy GABA, β-alanine, and δ-amino-valeric acid on neurons of the spinal cord and cerebral cortex of the rat were investigated.2.2. In the spinal cord strychnine and bicuculline were relatively specific antagonists of the actions of ‘glycine-like’ and ‘GABA-like’ amino-acids respectively. The specificity of picrotoxin as an antagonist of ‘GABA-like’ amino-acids was less than that of bicuculline.3.3. On most cortical neurons both bicuculline and picrotoxin non-specifically reduced the action of all depressant amino-acids. Strychnine had no effect until concentrations producing abnormalities in action potentials were used, when all depressants were equally reduced.4.4. It is suggested that in the rat the type of receptor for ‘glycine-like’ amino-acids present on spinal neurons is uncommon on neurons of the cerebral cortex, and that on these latter cells all the amino-acids studied acted through combination with one type of receptor.

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