In vitro cytotoxicity of carbazole derivatives IV. 5,11-Dimethyl-6H-pyrido[3,2-b]carbazoles substituted on the pyridine ring

Add time:08/29/2019    Source:sciencedirect.com

A series of 5,11-dimethyl-6H-pyrido[3,2-b]carbazoles, structurally related to the antitumor drug ellipticine, were synthesized from 3-amino-1,4-dimethyl-9H-carbazole. Among 17 derivatives, bearing various substituents on the pyridine ring, and preliminarily evaluated for cytotoxicity on L1210-cultured cells, 13 (76%) were found to be active. One of them, 5,11-dimethyl-4-ethoxy-6H-pyrido[3,2-b]carbazole, although non-substituted on C-9, displayed an activity similar to that of 9-hydroxy-N-2-methylellipticinium acetate. Structure-activity relationships have been described in detail.

We also recommend Trading Suppliers and Manufacturers of 1,4-dihydro-4-oxo-2,5,11-trimethyl-6H-pyrido(3,2-b)carbazole (cas 111249-53-7). Pls Click Website Link as below: cas 111249-53-7 suppliers

Prev:Generation of ortho-quinone methides upon thermal extrusion of sulfur dioxide from benzosultones
Next:Acid catalyzed condensation of levulinic acid with glyoxylic acid: synthesis of 1-methyl-2,8-dioxabicyclo[3.3.0]oct-4-ene-3,7-dione)