Oxime functionality in surfactant self-assembly: An overview on combating toxicity of organophosphates

Add time:08/30/2019    Source:sciencedirect.com

There is an immediate need to develop new strategies for detoxification and decontamination of organophosphorus-containing nerve agents and pesticides. Oximes have witnessed increased scientific interest because of their various applications ranging from acetylcholinesterase reactivators, independent alpha nucleophiles to functionalized nano-aggregates against organophosphate toxicity. The role of oximes as supernucleophilic systems in detoxification reactions is an important research theme and substantial efforts have been made in this report to address this fact. The results have been rationalized in terms of micellar kinetic studies in relation to the oxime structure. The reactivity of oximate ions in cationic micelles, as functionalized aggregates, as reactive polymers and metallomicelles has been well reviewed. Amidoximes emerging as versatile tool in detoxification chemistry has been discussed marginally in the present report. This article motivates similar kinds of studies from different viewpoints. Such studies can be extended to other micellar systems with versatile hydrophobic and hydrophilic properties.

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