Comparative pharmacological actions of ciguatoxin and tetrodotoxin, a preliminary account☆

Add time:09/02/2019    Source:sciencedirect.com

The pharmacological actions of ciguatoxin (methanol-soluble extract) have been investigated, and comparisons drawn with the reported effects of crystalline tetrodotoxin. The ciguatoxin displayed a greater toxicity to the crayfish than to the mouse. The toxin caused an extended depression in the blood pressure of rats, and it appeared that the failure of respiration induced by the extract has a relationship, both direct and indirect, to the depressor action. The toxin did not cause physostigmine-like activation on the electroencephalogram tracings in mice. In large doses it caused bradycardia, and the appearance of arrhythmia was regarded as a prodrome of death. Ciguatoxin and tetrodotoxin produced similar toxic signs, but there seem to be qualitative pharmacological differences between the two.

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