Subchapter 40A - Lys-Conopressin

Add time:08/29/2019    Source:sciencedirect.com

Lys-conopressin was isolated from the pond snail Lymnaea stagnalis, and consists of nine amino acids containing consensus amino acids of the OXT/VP superfamily peptides: Cys1, Asn5, Cys6, Pro7, Gly9; and C-terminal amidation. The Lys-conopressin gene in the pond snail is composed of three exons and two introns at exactly the same locations as in the OXT/VP genes of vertebrates. Two Lys-conopressin receptors (LSCPR1 and LSCPR2) have also been identified from the pond snail, and both LSCPR genes are expressed in the brain and reproductive tissues. Lys-conopressin evokes Ca2+-dependent Cl− currents in Xenopus oocytes injected with LSCPR cRNAs. Lys-conopressin potently induces contractions in the vas deferens, indicating that Lys-conopressin is involved in the ejaculation of semen during intromission in the pond snail. In addition, Lys-conopressin has been discovered in a leech, Erpobdella octoculata.

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