A simple and efficient approach to 1,3-aminoalcohols: application to the synthesis of (+)-negamycin

Add time:08/29/2019    Source:sciencedirect.com

A short and practical enantioselective synthesis of (+)-negamycin has been achieved in high enantio- and diastereomeric excess using an iterative Jacobsen’s hydrolytic kinetic resolution as the key step.

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